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Helicobacter pylori cagA Gene and Host Interleukin-1 Beta and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Gastric Carcinoma
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 대한소화기학회지 = The Korean journal of gastroenterology |
| ISSN | 1598-9992, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Lee, Jae Seung,Kim, Gwang Ha,Heo, Jeong,Park, Do Youn,Jun, Eun Sook,Kang, Dae Hwan,Song, Geum Am,Cho, Mong,Yang, Ung Suk |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2003-01-01 |
| 초록 | BACKGROUND/AIMS: Both Helicobacter pylori (H. pylori) cagA genotype and host interleukin-1 beta/interleukin-1 receptor antagonist (IL-1B/IL-1RN) gene polymorphisms play a role in determining the clinical consequences of H. pylori infection. In this study, we investigated H. pylori cagA genotype and host IL-1B/IL-1RN polymorphisms in Korean patients to clarify their involvement in the occurrence of gastric carcinoma. METHODS: The population comprised of 134 patients with H. pylori infection: 82 with gastric carcinoma and 52 with gastritis. The DNA was isolated from gastric biopsy sample and H. pylori cagA genotype was determined by PCR. The IL-1B-511 polymorphism was genotyped by PCR-RFLP and the IL-1RN polymorphism was analyzed. RESULTS: Infection with cagA+ H. pylori was not associated with an increased risk for gastric carcinoma. The IL-1B-511 *T carriers and IL-1RN *2 carriers did not show an increased risk for gastric carcinoma. Combining bacterial/host genotypes, cagA+/IL-1B-511 *T carriers and cagA+/IL-1RN *2 carriers showed no increased risk of gastric carcinoma. Classifying of gastric carcinoma into intestinal and diffuse type, the bacterial/host genotypes were also not associated with increased risk of each type. CONCLUSIONS: Combined H. pylori cagA gene and host IL-1B/IL-1RN polymorphisms showed no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors might play more important roles in the development of gastric carcinoma in Korean. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART48216825 |
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추가정보
| 과학기술표준분류 | |
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| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Interleukin-1,Receptors,interleukin-1,Interleukin-1 receptor antagonist,Polymorphism,Stomach neoplasms |