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Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF- alpha; related mechanism
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | The Korean journal of physiology pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| ISSN | 1226-4512, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Tian, Shuying,Guo, Ruixue,Wei, Sichen,Kong, Yu,Wei, Xinliang,Wang, Weiwei,Shi, Xiaomeng,Jiang, Hongyu |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2016-01-01 |
| 초록 | Present study aimed to investigate the effect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin groups (n=10). Animals in curcumin group were pretreated with curcumin by gastric gavage (200 mg/kg) for 2 days before I/R. Small intestine tissues were prepared for Haematoxylin Eosin (H E) staining. Serum diamine oxidase (DAO) and tumor necrosis factor (TNF)- ${ alpha}$ levels were measured. Expression of intestinal TNF- ${ alpha}$ and tight junction protein (ZO-1) proteins was detected by Western blot and/or immunohistochemistry. Serum DAO level and serum and intestinal TNF- ${ alpha}$ leves were significantly increased after I/R, and the values were markedly reduced by curcumin pretreatment although still higher than that of sham group (p ${ alpha}$ related pathway. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201608949924087 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Curcumin,Intestine,Intestinal mucosa barrier,Intestinal permeability,Ischemia/reperfusion (I/R) injury,Tight junction protein (ZO-1) |