| 초록 |
This study was performed to evaluate the acute toxicity of DA-3030(granulocyte-colony stimulating factor, G-CSF) in mice and rats via intragastrical and intravenous routes. DA-3030(G-CSF) in the acute toxicity study did not induce any toxic signs in the mice and rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD $_{50}$ values in mice and rats would be gt;13, 800 $ mu textrm{g}$ /kg in the oral route and gt;6, 900 $ mu textrm{g}$ /kg in the intravenous route.e. |