| 저자(한글) |
Kim, Young Ock,Lee, Sang Won,Yang, Seung Ok,Na, Sae Won,Kim, Su Kang,Chung, Joo Ho |
| 초록 |
In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of central nervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower could influence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day (200 mg/kg body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreased the induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedly decreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances (TBARS) ( $55.2{ pm}9.4{ mu}mol ;mg^{-1}$ ) and significant improvement of activities of glutathione (GSH) ( $27.2{ pm}5.0{ mu}mol ;mg^{-1}$ ) in hippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell loss induced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment of vascular dementia. |
