| 초록 |
This study was to investigate anti-skin wrinkle effect of Agastache rugosa Kentz extracts by extraction processes. In the comparison of the effect of the solvent extraction, the extracts by 70% ethanol (EE) showed better biological activities that those by hot water. Therefore, further fermented Agastache rugosa was applied to 70% ethanol extraction process (FEE). FEE showed higher DPPH scavenging activity of 62.98% than EE's 62.71% at $1.0mg/m{ ell}$ , but there was no significant. Elastase inhibition was measured 23.0% from FEE at $1.0mg/m{ ell}$ . Cytotoxicity showed the highest 16.26% from FEE, this value is safe in the cell experiment. Collagen production showed $113.1ng/m{ ell}$ from FEE, on the other hand EE was measured $77.4ng/m{ ell}$ in adding $1.0mg/m{ ell}$ . MMP-1 production was observed $1398pg/m{ ell}$ from FEE and EE was measured $1632pg/m{ ell}$ . These results were found the highest antioxidant and anti-wrinkle effect. As a result, it was also confirmed that anti-skin wrinkle activities of the Agastache rugosa Kentz extract was correlated with anti-oxidant activities. |
