| 저자(한글) |
Li, Chunxia,Zhang, Hui,Qu, Jin,Dai, Jun,Ma, Qun,Li, Zhihua,Wang, Bo,Si, Chuanping |
| 초록 |
Objective To detect the expression of interleukin 16 (IL-16) in skin allografts of recipient mice and the serum level of IL-16. Methods Two different mouse models of skin allografts were used: the isotransplant group (C57BL/6--C57BL/6, n=45) and the allotransplantation group (BALB/c--C57BL/6, n=45). The level of IL-16 in sera and skin graft homogenates was tested by ELISA at 1, 3, 5 and 7 days after transplantation and the expression of IL-16 mRNA in skin allografts was measured by reverse transcription PCR at the same time points. Results At 3, 5 and 7 days after skin transplantation, the levels of IL-16 protein and mRNA in the skin allografts and serum level of IL-16 in the allotransplantation group were significantly higher than those in the isotransplant group. Conclusion The expression of IL-16 is increased in the mouse skin allografts. |
