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[Interleukin-37 inhibits the motility and migration of mouse splenic dendritic cells].
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 細胞與分子免疫學雜誌 = Chinese journal of cellular and molecular immunology |
| ISSN | 1007-8738, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Luo, Yuechen,Liu, Fang,Li, Wenwen,Wu, Wantong,Sun, Zhina,Zhao, Chunxiao,Shen, Yue |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2015-01-01 |
| 초록 | Objective To investigate the effect of interleukin-37 (IL-37) on the motility and migration of mouse splenic dendritic cells (DCs). Methods Magnetic bead cell sorting was used to isolate mouse splenic DCs, and flow cytometry was used to analyze the purity. DCs were visualized in real time by PerkinElmer laser confocal microscopy and analyzed by Volocity image analysis software. The alteration of chemokine (C motif) receptor 1 (XCR1) mRNA was revealed by microarray analysis and confirmed by real-time PCR and flow cytometry. Migration ability of DCs was detected by Transwell(TM) migration assay. Results The purity of isolated DCs was over 95%. The treatment of IL-37 reduced the velocity of DCs mobility, decreased XCR1 expression and depressed the cell migration ability. Conclusion IL-37 can inhibit the motility and migration of mouse splenic DCs. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART73411388 |
| 첨부파일 |
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