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논문

[IL-18 and TNF-관 promote the expression of IL-18R관 in 3T3-L1 adipocytes and RAW264.7 macrophages].

기관명, 저널명, ISSN, ISBN 으로 구성된 논문 개요 표입니다.
기관명	NDSL
저널명	細胞與分子免疫學雜誌 = Chinese journal of cellular and molecular immunology
ISSN	1007-8738,
ISBN

저자, 소속기관, 출판인, 간행물 번호, 발행연도, 초록, 원문UR, 첨부파일 순으로 구성된 논문저자 및 소속기관 정보표입니다
저자(한글)	Jin, Guoxi,Zhang, Yan,Bi, Yaxin,Yu, Lei
저자(영문)
소속기관
소속기관(영문)
출판인
간행물 번호
발행연도	2015-01-01
초록	Objective To explore the effects of interleukin 18 (IL-18) and tumor necrosis factor alpha (TNF-관) on the expression of IL-18 receptor beta (IL-18R관) in 3T3-L1 adipocytes and RAW264.7 macrophages. Methods The level of IL-18R관 was determined by reverse transcription PCR and Western blotting in both 3T3-L1 adipocytes and RAW264.7 macrophages after processed by different concentrations of IL-18 and TNF-관. Results The level of IL-18R관 mRNA and protein significantly increased in 3T3-L1 adipocytes after treated with 10 ng/mL, 100 ng/mL TNF-관. The expression of IL-18R관 was also raised in RAW264.7 macrophages after treated with 10 ng/mL, 100 ng/mL IL-18. Conclusion IL-18R관 could be up-regulated by IL-18 or TNF-관 in 3T3-L1 adipocytes and RAW264.7 macrophages. IL-18 may be an important factor involved in the inflammation of adipose tissues in diabetes and obesity.
원문URL	http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART73411384
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