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[The frequency of peripheral blood CD14(+)HLA-DR(-/low) MDSCs is negatively correlated with the inflammation in patients with chronic hepatitis B].
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 細胞與分子免疫學雜誌 = Chinese journal of cellular and molecular immunology |
| ISSN | 1007-8738, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Zhang, Hao,Guan, Shihe,Yang, Kai,Ye, Jun,Yan, Kaili,Pan, Ying,Wu, Yuanyuan,Wang, Aihua,Sun, Beibei |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2015-01-01 |
| 초록 | Objective To study the frequency of CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells (MDSCs) in the peripheral blood of chronic hepatitis B (CHB) patients and the relationship with biochemical characteristics, viral load and liver pathology. Methods The frequency of CD14(+)HLA-DR(-/low) MDSCs in the peripheral blood of 96 patients with CHB and 20 healthy control cases were detected by flow cytometry. Ultrasound-guided liver biopsies as well as HBV-related serological tests were performed in HBV-infected individuals to analyze the biochemical characteristics, viral load and pathology. The data were assessed using Spearman correlation analysis. Results The frequency of the peripheral blood CD14(+)HLA-DR(-/low) MDSCs in the 96 CHB cases was (6.03 #177;0.09)%, which was significantly higher than that of the 20 healthy control cases (1.87 #177;0.05)%. The group of HBeAg positive cases had a significantly higher frequency of the peripheral blood CD14(+)HLA-DR(-/low) MDSCs compared with the group of HBeAg negative cases and the healthy control group. The frequency of CD14(+)HLA-DR(-/low) MDSCs in the peripheral blood was negatively correlated with serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. There was no correlation between the frequency of peripheral blood CD14(+)HLA-DR(-/low) MDSCs and HBV load. The frequency of CD14(+)HLA-DR(-/low) MDSCs in the peripheral blood was negatively correlated with the liver inflammation grade, but not related with the fibrosis stage in patients with CHB. Conclusion The frequency of CD14(+)HLA-DR(-/low) MDSCs is negatively correlated with the inflammation of CHB. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART74273029 |
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