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논문 기본정보
프리온 병원체에 감염된 마우스 해마부위에서 Malondialdehyde 및 Hydroxynonenal에 의해 수식된 단백질들의 침착
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | Journal of bacteriology and virology : JBV |
| ISSN | 1598-2467,2093-0429 |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 김재일,이형곤 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2008-01-01 |
| 초록 | Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are rare and fatal neurodegenerative conditions that affect both humans and animals. Although there is increased evidence that oxidative stress plays an important role in the pathogenesis of these diseases, the direct relationship between an accumulation of abnormal prion protein ( $PrP^{Sc}$ ) and the occurrence of oxidative stress has not been studied. In the present study, we have investigated the cellular localization of proteins modified by lipid peroxidation end products and its correlation with $PrP^{Sc}$ accumulation in the brain of mice infected with the ME7 prion strain. Intense immunostaining of malondialdehyde (MDA)- and hydroxynonenal (HNE)-modified proteins were observed in the hippocampus of prion-infected mice. In serial section study, we found that these immunoreactivities were co-localized with glial fibrillary acidic protein (GFAP)-positive astrocytes as well as with $PrP^{Sc}$ . These results clearly indicate that the heightened oxidative stress in the form of lipid peroxidation is closely associated with $PrP^{Sc}$ accumulation in astrocytes of prion-infected mice. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO200814357768441 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Prion diseases,Oxidative stress, lt,TEX gt,$PrP^{Sc}$ lt,/TEX gt,. Lipid peroxidation end products,Astrocytes |