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논문 기본정보
Isoproterenol에 의한 자궁근 이완의 기전 : 4-aminopyridine-sensitive K+ 채널의 개방
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 大韓獸醫學會誌 = Korean journal of veterinary research |
| ISSN | 1225-0198,2234-134x |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 김기하,이영재,조명행,이문한,전보권,류판동 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 1996-01-01 |
| 초록 | Activation of $K^+$ channels induces relaxation of smooth muscles by reducing electrical excitability and cytosolic free $Ca^{2+}$ level. ${ beta}$ -adrenergic agonist isoproterenol is known to induce relaxation of the uterine smooth muscle by membrane hyperpolarization and $K^+$ efflux. Recently it is suggested that the activity of $Ca^{2+}$ -activated $K^+$ channel was increased by isoproterenol in the uterine myocytes isolated from myometrium of the pregnant rat. However, the type of $K^+$ channel mediating the relaxant effect of isopreterenol in the tissue level has not yet studied. In this work, we investigated the type of $K^+$ channels involved in the isoproterenol-induced relaxation of uterine smooth muscle by measuring the integrated insometric tension of the estrogen-treated isolated nonpregnant rat uterus. Contraction of uterine tissue was induced by oxytocin (0.2nM, 2~3 contractions/min) or high KCl(20~80mM). The result are as follows : 1. Isoproterenol( $10^{-10}{ sim}10^{-4}M$ ) inhibited oxytocin-induced contraction of isolated rat uterus( $EC_{50}=1.17{ times}10^{-10}M$ ). 2. Isoproterenol( $10^{-10}{ sim}10^{-4}M$ ) effectively inhibited uterine contraction induced by low KCl(20~40mM) but little those induced by high KCl(60~80mM). 3. Relaxant effect of isoproterenol( $10^{-10}{ sim}10^{-4}M$ ) on 0.2nM oxytocin-induced contraction was effectively reduced by 4-aminopyridine(3, 10mM) but little by TEA(10~30mM), $Ba^{2+}$ ( $1{ sim}30{ mu}M$ ) and glibenclamide( $100{ mu}M$ ). Our data suggest that the relaxant effect of isoproterenol is mediated by the $K^+$ channel(s) which can be blocked by 4-aminopyridine. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO199624457071259 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | isolated uterus,oxytocin,KCl,isoproterenol, lt,TEX gt,$K^+$ lt,/TEX gt,. channel blockers |