| 저자(한글) |
Kwon, Oran,Lee, Sunho,Ban, Soonhyun,Im, Jooyeon J.,Lee, Doo Suk,Lee, Eun Hee,Kim, Joohee,Lim, Soo Mee,Lee, Sang Gon,Kang, Ilhyang,Kim, Kyung-Hee,Yoon, Sujung,Lee, Sun Hea |
| 초록 |
Objectives The combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints. Methods Seventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebo-controlled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed. Results The herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p |
