| 저자(한글) |
Baik, Ji-Sue,Mun, Seo-Won,Kim, Kyoung-Sook,Park, Shin-Ji,Yoon, Hyun-Kyoung,Kim, Dong-Hyun,Park, Min-Kyu,Kim, Cheorl-Ho,Lee, Young-Choon |
| 초록 |
We first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in U87MG cells with wild-type p53, but not in T98G cells with mutant-type p53. Western blot data revealed that the levels of procaspase-8, -3, and Bcl-2 were downregulated in cordycepin-treated U87MG cells, whereas the levels of Fas, FasL, Bak, cleaved caspase-3, -8, and cleaved PARP were upregulated, indicating that cordycepin induces apoptosis by activating the death receptor-mediated pathway in U87MG cells. Cordycepin-induced apoptosis could be suppressed by only SB203580, a p38 MAPK-specific inhibitor. These results suggest that cordycepin triggered apoptosis in U87MG cells through p38 MAPK activation and inhibition of the Akt survival pathway. |
