| 초록 |
Among extracts prepared from Alstonia scholaris, Phyllostachys pubescens and Bambusa veitchii, methanol fraction of Alstonia scholaris was found to have antiplasmodial effect by inhibiting growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with less than 14 mu;g/ml of EC50 values. Methanol fraction 2 of Alstonia scholaris revealed the strongest anti plasmodial effect with 40 mu;g/ml of EC50 value. Especially, this fraction showed higher than 3-folds selective toxicity on a Plasmodium as the EC value was 116 mu;g/ml on the host FM3A cell. This is the first report on which an extract compound from Alstonia scholaris showed antimalarial effect. |
