| 초록 |
Background: Dexmedetomidine is known to be administered for sedation safely even in a very elderly patient. The purpose of this study was to determine the effect of age on clinically optimal dose of dexmedetomidine for sedation. Methods: We enrolled 50 patients ASA class I and II, scheduled for lower extremity surgery that need. They were classified into a young group (n = 26), aged below 75 and an old group (n = 24), aged above 75. Dexmedetomidine was continuously infused $0.5{ mu}g/kg$ within 10 min, followed by maintenance at a dose of $0.5{ mu}g/kg/min$ , initially. The next dose was selected using the Dixon's up-and-down method. Results: The cED50 of dexmedetomidine required to maintain optimal sedation level in young and old group were 0.50 and $0.48{ mu}g/kg$ , respectively. With isotonic regression, cED95 of dexmedetomidine was $0.71{ mu}g/kg$ (95% confidence intervals $0.57-1.06{ mu}g/kg$ ) and $0.58{ mu}g/kg$ (95% confidence intervals $0.51-0.67{ mu}g/kg$ ). There were no significant differences in cED50 (P = 0.21), recovery variables, or incidence of side effects between the two groups. Conclusions: Clinically optimal dose of dexmedetomidine was not affected to the age during sedation. |
