| 저자(한글) |
Choi, Il-Dong,Kim, Sung-Hwan,Jeong, Ji-Woong,Lee, Dong Eun,Huh, Chul-Sung,Hong, Seong Soo,Sim, Jae-Hun,Ahn, Young-Tae |
| 초록 |
The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 × 10 9 CFU/day of L. plantarum KY1032 and 5 × 10 9 CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPAR alpha;, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPAR alpha;, and FXR. |
