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논문 기본정보
The effect of progesterone and 17- #x03B2; estradiol on membrane-bound HLA-G in adipose derived stem cells
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | The Korean journal of physiology pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| ISSN | 1226-4512, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Moslehi, Akram,Hashemi-beni, Batool,Moslehi, Azam,Akbari, Maryam Ali,Adib, Minoo |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2016-01-01 |
| 초록 | Membrane-bound HLA-G (mHLA-G) discovery on adipose derived stem cells (ADSCs) as a tolerogenic and immunosuppressive molecule was very important. Many documents have shown that HLA-G expression can be controlled via some hormones such as progesterone (P4) and estradiol (E2). Therefore, this study was designed to evaluate progesterone and estradiol effects on mHLA-G in ADSCs at restricted and combination concentrations. Three independent cell lines were cultured in complete free phenol red DMEM and subcultured to achieve sufficient cells. These cells were treated with P4, E2 and P4 plus E2 at physiologic and pregnancy concentrations for 3 days in cell culture conditions. The HLA-G positive ADSCs was measured via monoclonal anti HLA-G-FITC/ MEMG-09 by means of flow cytometry in nine groups. Data were analyzed by one way ANOVA and Tukey's post hoc tests. There were no significant values of the mean percentage of HLA-G positive cells in E2-treated and the combination of P4 plus $E_2-treated$ ADSCs compared to control cells (p value gt;0.05) but P4 had a significant increase on mHLA-G in ADSCs (p value |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201620340965329 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
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| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Adipose derived stem cell,Estradiol,Membrane-bound HLA-G,Progesterone |