| 저자(한글) |
YU, Yongsheng,TANG, Zhenghao,ZHANG, Ronggui,FENG, Jie,XI, Min,ZANG, Guoqing |
| 초록 |
OBJECTIVE To investigate CD_(25) expression in peripheral blood T lymphocytes from patients with chronic hepatitis B,and explore its significance in the pathogenesis of chronic hepatitis B.METHODS To detect CD_(25) expression in peripheral blood T lymphocytes of patients with chronic hepatitis B by means of flow cytometry.CD_(25) expression was observed in chronic hepatitis B patients.In the meantime,CD_(25) expression in T cells from severe chronic hepatitis or acute hepatitis B patients and asymptomatic carriers of HBV was also observed.RESULTS Varying degrees of CD_(25) were expressed in T cells from hepatitis B patients.The expression in CD_3~+ T and CD_8~+T cells was higher than that in CD_4~+T cells.CD_(25) expression in CD_4~+T was lower.The average of CD_(25) expression in CD_3~+T cells from patients with chronic hepatitis B,acute hepatitis B,and chronic severe hepatitis B and asymptomatic carriers of HBV was(2.92±0.13)%,(0.51±0.36)%,(1.60±0.07)%,and(0.95±0.23)%,respectively.The average of CD_(25) expression in CD_4~+T cells from patients with chronic hepatitis B,acute hepatitis B and chronic severe hepatitis B and asymptomatic carriers of HBV was(2.58±0.50)%,(0.34±0.07)%,(1.45±0.02)%,and(0.83±0.13)%,respectively.CD_3~+T and CD_4~+T CD_(25) expression in patients with chronic hepatitis and,severe chronic hepatitis B was increased compared with that of acute hepatitis B patients and asymptomatic carriers of HBV.Compared with chronic severe hepatitis B,the expression of chronic hepatitis B was higher.CONCLUSIONS CD_4~+ CD_(25)~+T cells in chronic hepatitis B virus infection are increased compared with acute hepatitis,CD_4~+ CD_(25)~+T cells may be related to immune tolerance. |
