| 저자(한글) |
Nagahori, Kenta,Iwahashi, Kazuhiko,Narita, Shin,Numajiri, Maki,Yoshihara, Eiji,Nishizawa, Daisuke,Ikeda, Kazutaka,Ishigooka, Jun |
| 초록 |
Schizophrenia and bipolar disorder show high comorbidity with smoking dependence. Several previous studies reported that glycogen synthase kinase 3관 (GSK3관), which is widely expressed in the brain including the dopamine projection areas such as the amygdala, nucleus accumbens and hippocampus, may play a role in neuropsychiatric disorders and dopamine- and serotonin-mediated behavior. In this study, we have analyzed the association of three single nucleotide polymorphisms (SNPs) within GSK3관 gene (rs3755557, rs334558, rs6438552) with the smoking habits and age at smoking initiation in a sample of 384 young adult Japanese, which included 172 smokers and 212 non-smokers. As a result, rs334558 was significantly associated with smoking habits in genotype frequency and allelic frequency (P |
