시메티딘 정맥투여가 사이크로스포린의 체내동태에 미치는 영향
기관명 | NDSL |
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저널명 | 한국임상약학회지 = Korean journal of clinical pharmacy |
ISSN | 1226-6051, |
ISBN |
저자(한글) | 최인,최준식 |
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저자(영문) | |
소속기관 | |
소속기관(영문) | |
출판인 | |
간행물 번호 | |
발행연도 | 2000-01-01 |
초록 | The effect of cimetidine on the pbarmacokinetic parameters of cyclosporine (intravenous administration) were determined in 6 healthy volunteers (22-48 years old, 48-62 kg) by cross-over design. Cyclosporine and cyclosporine metabolites in whole blood were analysed by fluororescence polarization immunoassay (TDx-FLX). The blood concentrations of cyclosporine After pretreatment with cimetidine (200 mg bid, for 3days) were increased significantly at 8-12 hrs compared to the control (p $(AUC, %)$ was increased but not significant. |
원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO200007921845024 |
첨부파일 |
과학기술표준분류 | |
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ICT 기술분류 | |
DDC 분류 | |
주제어 (키워드) | Cyclosporine,Cimetidine,Cyclosporine metabolites (M1, M17),Pharmacokinetic parameter,Human volunteers |