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논문 기본정보
추출조건에 따른 배암차즈기 추출물의 지방세포 분화 및 지방축적 억제 효과
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 韓國藥用作物學會誌 = Korean journal of medicinal crop science |
| ISSN | 1225-9306, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 최수임,곽호영,김재윤,최종길,이제혁 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2015-01-01 |
| 초록 | This study was carried out to investigate the effects of Salvia plebeia R. Br. ethanolic extract with different aspects (stem/leaf and whole plant) on differentiation and lipid accumulation in 3T3-L1 preadipocytes. The morphological changes and the degrees of lipid accumulation in 3T3-L1 cells were measured by Oil Red O staining and intra-cellular triglyceride (TG) assay. The mRNA expressions of special peroxisome proliferation activated receptor- genes (PPAR), CCAAT/ enhancer-binding protein (C/ $EBP{ alpha}$ ), fatty acid synthase (FAS) and lipoprotein lipase (LPL) were detected by reverse transcriptase polymerase chain reaction (RT-PCR). The 50% ethanolic extracts ( $100{ mu}g/mL$ ) of stem and leaf (SALE) and 30% ethanolic extracts (100 g/mL) of whole plant (SAE) from Salvia plebeia R. Br. were significantly attenuated lipid accumulation during adipogenesis in 3T3-L1 cells. Ethyl acetate-soluble fractions ( $50{ mu}g/mL$ ) significantly inhibited lipid droplet accumulation in 3T3-L1 cells. In addition, SALE induced down-regulation of specific adipogenic transcriptional factors (C/ $EBP{ alpha}$ and $PPAR{ gamma}$ ) and target genes (FAS and LPL) during adipogenesis. Salvia plebeia R. Br. may be used as a safe and efficient natural substance to manage obesity. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201520441373358 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Salvia plebeia,3T3-L1,Adipogenesis,C/ lt,TEX gt,$EBP{ alpha}$ lt,/TEX gt,. lt,TEX gt,$PPAR{ gamma}$ lt,/TEX gt,. FAS,LPL |