| 저자(한글) |
Min, Sang Woon,Shon, Young Hae,Park, Chang Hwan,Lee, Wan Sik,Joo, Young Eun,Choi, Sung Kyu,Rew, Jong Sun,Park, Chang Soo,Kim, Sei Jong |
| 초록 |
BACKGROUND/AIMS: The mechanism that controls cyclooxygenase-2 (COX-2) expression is not clear yet. Recently, it is reported that COX-2 expression is significantly high in the presence of mutated p53 genes. Thus, we investigated the expression of COX-2 and p53 in each stage of chronic gastritis, intestinal metaplasia, dysplasia, and gastric cancer, and studied their correlations. METHODS: The expressions of COX-2 and p53 in 128 local lesions were assessed immunohistochemically by using Micro-Probe System in a total of 101 patients. There were 23 chronic gastritis, 50 intestinal metaplasia, 34 dysplasia, and 21 intestinal type of gastric cancer. RESULTS: The expression of COX-2 was increased in 30.4% (7/23) of chronic gastritis, 68% (34/50) of intestinal metaplasia, 82.3% (28/34) of dysplasia, and 85.7% (18/21) of intestinal type gastric cancer. The expression of COX-2 was significantly increased as the disease progressed into gastric cancer (p |
