- HOME
- 홈페이지 이용안내
논문 기본정보
The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | BMB reports |
| ISSN | 1976-6696,1976-670x |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Altintas, Ozlem,Park, Sangsoon,Lee, Seung-Jae V. |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2016-01-01 |
| 초록 | Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201612454976110 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Aging,C. elegans,D. melanogaster,Insulin/IGF-1 signaling,Longevity |