| 저자(한글) |
WU, Weiyuan,PAN, Xiaomei,LU, Yuemei,WU, Jinsong,CHENG, Jine,GAN, Zhibiao,LI, Honglin |
| 초록 |
OBJECTIVE To investigate the prevalence of multidrug resistance (MDR) mechanisms of Staphylococcus haemolyticus against oxacillin, gentamycin and erythromycin. METItODS Agar dilution method was performed to detect the minimal inhibition concentration (MIC) of 3 antimicrobial agents against 63 strains of S. haemolyticus, and the resistance genes of mecA, aac(6')+ aph(2''), ermA, ermB, ermC and msrA/msrB were investigated by PCR in all clinical isolates. RESULTS mecA Gene was detected in 62 isolates of meticillin-resistant S. haemolyticus (MRSH), and aac (6')+aph(2'') gene was found in 50 isolates resistant to gentamicin, and the most prevalence erythromycin resistance gene in S. haemolyticus was msrA/msrB (58. 7%), followed by ermC (31.7 %). Among the 43 MDR strains, the more commonly encountered three genes were mecA, aac(6')+ aph (2'') and msrA/msrB (58. 1%)or ermC (20.9%),and 8 isolates (18.6%) were found harboring four genes of mecA, aac (6')+aph (2''), ermC and msrA/msrB. CONCLUSIONS The mecA, aac (6')+aph (2''), msrA/msrB and ermC genes are main resistance mechanisms against oxacillin, gentamicin and erythromycin in mutidrug resistant S. haernolyticus. |
