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논문 기본정보
Chrysosplenol C가 분리한 백서 심실 근세포 lt;TEX gt;$Ca^{2+}$ lt;/TEX gt; Transient에 미치는 효과
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 약학회지 |
| ISSN | 0377-9556, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 정석한,두 디 두 후옹,트란 반 성,뉘엔 만 콩,김영호,우선희 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2011-01-01 |
| 초록 | Chrysosplenol C [5,6-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxychromen-4-one] is a flavonoid found in Miliusa balansae and Pterocaulon sphacelatum. We have recently shown that chrysosplenol C has positive inotropic effect in isolated rat ventricular myocytes. In the present study, we explored a possible mechanism for the positive inotropic effect of chrysosplenol C by examining intracellular $Ca^{2+}$ transients during action potentials. The intracellular $Ca^{2+}$ transients were measured by confocal $Ca^{2+}$ imaging in field-stimulated single rat ventricular myocytes. Chrysosplenol C (50 ${ mu}M$ ) significantly increased the magnitudes ( ${ Delta}F/F_0$ ) of $Ca^{2+}$ transients (control, $1.08{ pm}0.05$ ; chrysosplenol C, $1.25{ pm}0.03$ ; n=8, P $Ca^{2+}$ transient was not altered by chrysosplenol C (50 ${ mu}M$ ) (control, $154{ pm}6$ ms; chrysosplenol C, $167{ pm}11$ ms; n=21). The $Ca^{2+}$ content in the sarcoplasmic reticulum (SR), measured as caffeine (10 mM)-induced $Ca^{2+}$ transient, was significantly decreased by chrysosplenol C (50 ${ mu}M$ ). These results indicate that chrysosplenol C increases $Ca^{2+}$ transients without altering $Ca^{2+}$ removal kinetics in ventricular myocytes, providing a possible mechanism for its positive inotropic effect. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201121055566521 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | chrysosplenol C,intercellular lt,TEX gt,$Ca^{2+}$ lt,/TEX gt,transient,ventricular myocytes,SR lt,TEX gt,$Ca^{2+}$ lt,/TEX gt,content, lt,TEX gt,$Ca^{2+}$ lt,/TEX gt,transient decay |