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논문 기본정보
Prognostic value of pretreatment 18F-FDG PET-CT in radiotherapy for patients with hepatocellular carcinoma
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | Radiation oncology journal : ROJ |
| ISSN | 2234-1900,2234-3156 |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Jo, In Young,Son, Seok-Hyun,Kim, Myungsoo,Sung, Soo Yoon,Won, Yong Kyun,Kang, Hye Jin,Lee, So Jung,Chung, Yong-An,Oh, Jin Kyoung,Kay, Chul-Seung |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2015-01-01 |
| 초록 | Purpose: The purpose of this study was to investigate the predictable value of pretreatment lt;TEX gt;$^{18}F$ lt;/TEX gt;-fluorodeoxyglucose positron emission tomography-computed tomography ( lt;TEX gt;$^{18}F$ lt;/TEX gt;-FDG PET-CT) in radiotherapy (RT) for patients with hepatocellular carcinoma (HCC) or portal vein tumor thrombosis (PVTT). Materials and Methods: We conducted a retrospective analysis of 36 stage I-IV HCC patients treated with RT. lt;TEX gt;$^{18}F$ lt;/TEX gt;-FDG PET-CT was performed before RT. Treatment target was determined HCC or PVTT lesions by treatment aim. They were irradiated at a median prescription dose of 50 Gy. The response was evaluated within 3 months after completion of RT using the Response Evaluation Criteria in Solid Tumors (RECIST). Response rate, overall survival (OS), and the pattern of failure (POF) were analyzed. Results: The response rate was 61.1%. The statistically significant prognostic factor affecting response in RT field was maximal standardized uptake value (maxSUV) only. The high SUV group (maxSUV lt;TEX gt;${ geq}5.1$ lt;/TEX gt;) showed the better radiologic response than the low SUV group (maxSUV lt; 5.1). The median OS were 996.0 days in definitive group and 144.0 days in palliative group. Factors affecting OS were the %reduction of alpha-fetoprotein (AFP) level in the definitive group and Child-Pugh class in the palliative group. To predict the POF, maxSUV based on the cutoff value of 5.1 was the only significant factor in distant metastasis group. Conclusion: The results of this study suggest that the maxSUV of lt;TEX gt;$^{18}F$ lt;/TEX gt;-FDG PET-CT may be a prognostic factor for treatment outcome and the POF after RT. A %reduction of AFP level and Child-Pugh class could be used to predict OS in HCC. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201532751505698 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Radiotherapy,Positron emission tomography,Hepatocellular carcinoma |