| 저자(한글) |
Jung, Eun Sun,Bae, Si Hyun,Jang, Jeong Won,Choi, Jong Young,Yoon, Seung Kew,Chung, Kyu Won,Sun, Hee Sik,Park, Doo Ho,Kim, Byung Ki |
| 초록 |
BACKGROUND/AIMS: The aim of this study was to examine the histological changes of the liver after a 3-year lamivudine therapy in patients with chronic hepatitis B. METHODS: Seven patients with sustaining virological and biochemical response were enrolled in this study. The patients were given lamivudine orally at a dose of 100 mg for 3 years, and then, the second liver biopsy was performed. The liver biopsies were evaluated using the conventional histological assessment scale and the quantification of fibrosis by an image analysis. RESULTS: All patients showed a reduction in the hepatic necro-inflammatory activity after 3 years of lamividine therapy compared to the pretreatment value as follows: the mean grade of lobular activity, 1.14 vs. 2.28; porto-periportal activity grade, 1 vs. 2.57; fibrosis stage 1.14 vs. 2.14. The quantification by the image analysis showed a significant reduction of the fibrotic area in the mean portal, periportal, and septal portions (17, 985 vs. 7, 082 um2, p |
