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논문 기본정보

高分子結合性ペプチドを用いた機能性ソフト界面の創製

논문 개요

기관명, 저널명, ISSN, ISBN 으로 구성된 논문 개요 표입니다.
기관명 NDSL
저널명 表面科學 = Journal of the Surface Science Society of Japan
ISSN 0388-5321,1881-4743
ISBN

논문저자 및 소속기관 정보

저자, 소속기관, 출판인, 간행물 번호, 발행연도, 초록, 원문UR, 첨부파일 순으로 구성된 논문저자 및 소속기관 정보표입니다
저자(한글) 伊達 隆明,芹澤 武
저자(영문)
소속기관
소속기관(영문)
출판인
간행물 번호
발행연도 2012-01-01
초록 We demonstrated the selection and characterization of polymer-binding peptides, and their application as surface modifiers. Peptides that bind specifically to polyetherimide (PEI) films were successfully identified from a phage-displayed peptide library. A chemically-synthesized peptide with the sequence of Thr-Gly-Ala-Asp-Leu-Asn-Thr (p1) showed high affinity toward PEI films (5.6×10 8 M -1 ). The peptide was biotinylated and immobilized onto the PEI films to function as a linker for the subsequent immobilization of streptavidin (SAv). We found that several factors could significantly affect the amount of SAv bound. Furthermore, we demonstrated that the SAv immobilized onto the PEI films via the biotinylated peptides was uniformly distributed, and thus was able to further immobilize probe DNA and to observe hybridization with complementary DNA. The present study offered new and significant insights into the modification of polymer film surfaces with specific binding peptides.
원문URL http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART58437236
첨부파일

추가정보

과학기술표준분류, ICT 기술분류,DDC 분류,주제어 (키워드) 순으로 구성된 추가정보표입니다
과학기술표준분류
ICT 기술분류
DDC 분류
주제어 (키워드) soft interface,surface modification,polymer-binding peptide,polyetherimide