| 초록 |
The phannacokinetics and tissue distribution of DWQ-013, a new quinolone, were examined in rats and mice following a single intravenous and oral administration. DWQ-013 in plasma and urine was determined by both HPLC and microbiological assay. The plasma concentration of the drug declined biexponentially. The terminal half life of the drug was 11.11 $ pm$ 0.14 hour after intravenous dosing. The volume of distribution at terminal elimination phase(Vd $_ beta$ ) and total clearance of the drug were 1.29 $ pm$ 0.15 l/kg and 0.78 $ pm$ 0.09 l/h/kg. The bioavailability of DWQ-013 after oral administration was 56.0% (HPLC) and 77.2%(bioassay), respectively. Twelve-hour urinary recovery of drug was measured by HPLC and bioassay to 0.035 $ pm$ 0009% and 4.71 $ pm$ 066% after oral dosing, to 0.055 $ pm$ 0.014% and 7.65 $ pm$ 1.53% after intravenous dosing, which may indicate the presence of biologically active metabolites. Binding of the drug to plasma proteins ranged from 97%~99% at various concentrations. The drug was highly distributed in order of liver, kidney and lung after 1.5 hours in mice. |
