| 초록 |
Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the 'peroxidatic' Cys ( $C_P$ ) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the $C_P$ -SH to cysteine sulfenic acid ( $C_P$ -SOH), which then reacts with another cysteine residue, named the 'resolving' Cys ( $C_R$ ) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews. |
