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논문 기본정보
Peroxiredoxins in Regulation of MAPK Signalling Pathways; Sensors and Barriers to Signal Transduction
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | Molecules and cells |
| ISSN | 1016-8478,0219-1032 |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Latimer, Heather R.,Veal, Elizabeth A. |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2016-01-01 |
| 초록 | Peroxiredoxins are highly conserved and abundant peroxidases. Although the thioredoxin peroxidase activity of peroxiredoxin (Prx) is important to maintain low levels of endogenous hydrogen peroxide, Prx have also been shown to promote hydrogen peroxide-mediated signalling. Mitogen activated protein kinase (MAPK) signalling pathways mediate cellular responses to a variety of stimuli, including reactive oxygen species (ROS). Here we review the evidence that Prx can act as both sensors and barriers to the activation of MAPK and discuss the underlying mechanisms involved, focusing in particular on the relationship with thioredoxin. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201606050646447 |
| 첨부파일 |
추가정보
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| 주제어 (키워드) | kinase,peroxiredoxin,phosphatase,redox,thioredoxin |