| 초록 |
Oxytetracycline (OTC) has been widely used in eel culture as a therapeutic and prophylactic agent because of its broad-spectrum activity against gram-positive and -negative bacteria. The oral treatment dosage of OTC approved for the treatment of edwardsiellosis, furunculosis and vibriosis in eel is 50 mg/kg/day for 3-7 days in Korea. To determine new optimum dose of OTC in eel, the pharmacokinetics of OTC after single oral administration (100 mg/kg B.W., 200 mg/kg B.W.) in cultured eel, Anguilla japonica was examined. In oral dosage of 100 and 200 mg/kg body weight, the highest plasma concentrations of OTC were 1.19±0.42 #13197;/ #13206; and 2.69±0.57 #13197;/ #13206;, respectively. Plasma concentrations of OTC were not detected after 720 h post-dose in all experiments. The kinetic profile of absorption, distribution and elimination of OTC in plasma wwas calculated fitting to a 1- and 2-compartment model by WinNonlin program. The following parameters were obtained for a single dosage of 100 and 200 mg/kg respectively: 1-compartment model, AUC= 82.48 and 432.68 #13197;*h/ #13206;, Tmax= 3.93 and 14.24 hr, Cmax= 0.94 and 2.34 #13205;/ #13206;; 2-compartment model, AUC= 448.73 and 530.65 #13197;*h/ #13206;, Tmax= 6.37 and 8.96 hr, Cmax= 0.90 and 3.21 #13205;/ #13206;. |
