| 초록 |
Taurine, 2-aminoethanesulfonic acid is widely distributed in animal tissues and has a variety of bio-logical activities. A recent worldwide study demonstrated beneficial effects of taurine on aging and age-associated disorders. In general, taurine levels in the brain decease when an animal is subjected to pathologic conditions such as ischemia-anoxia and seizure. But the taurine levles tend to increase in the brain in hypertensive state. In the present study, the blood-brain barrier (BBB) transport of [ $^3$ H]taurine was compared between spontaneously hypertensive rats (SHR) and normotensive Sprague-Dawley rats (SD) using intravenous injection technique in vivo. We also obtained pharmacokinetic parameters of plasma volume maker, [ $^{14}$ C] sucrose and [ $^3$ H]taurine after inject to rats simulatenously. BBB permeability surface area product (PS) value of [ $^3$ H]taurine in SHR (16 $ pm$ 2.9 $ times$ 10 $^{-3}$ ml/min/g) was significantly higher than that in SD (7.4 $ pm$ 0.8 $ times$ 10 $^{-3}$ ml/min/g). There is also significant difference for brain uptake of [ $^3$ H]taurine between SHR (0.195 $ pm$ 0.031%ID/g) and SD (0.058 $ pm$ 0.003% ID/g). This is due to difference of area under the plasma concentration-time curve (AUC) and that of total clearance (Class) between SHR and SD. No significant difference was indicated from other organ uptakes such as lung, heart, liver SHR and SD. But also kidney uptake was much higher in SHR. In conclusion, [ $^3$ H]taurine in plasma was slowly eliminated in SHR than in SD and uptake of [ $^3$ H]taurine in SHR is much higher than that of SD. This results suggest increased taurine level in the brain in hypertension state have an any effect on the brain uptake of taurine. |
