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논문 기본정보
흰쥐에서 nitrone계 항산화제인 lt;TEX gt;$ alpha$ lt;/TEX gt;-phenyl-n-tert-butyl nitrone(PBN)의 뇌 투과성 및 체내동태
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 약학회지 |
| ISSN | 0377-9556, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 이나영,강영숙 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2002-01-01 |
| 초록 | The nitrone-based free radical trapping reagent, $ alpha$ -phenyl-n-tert-butyl nitrone (PBN) has been proposed as therapeutic agent for stroke. We used this for model drug of development of new drug for neuroprotection. The purpose of this study was to evaluate the blood-brain barrier (BBB) permeability of PBN in Sprague-Dawly (SD) rats. The BBB transport of PBN was investigated in SD rats using internal carotid artery perfusion (ICAP) method at a rate of 4 m iota;/min for 15 second. We also obtained pharmacokinetic parameters of PBN using single intravenous injection technique. When we estimated BBB permeability of PBN with ICAP method, the brain volume of distribution of PBN was 60.0 $ pm$ 12.0 $ mu textrm{g}$ / iota;. The brain uptake of PBN after IV injection at 120 min was 0.15 $ pm$ 0.01%ID/g. The PBN was transported to the brain through the BBB well in rats, because PBN is small molecule (MW 177) and lipid-soluble (log P 1.23) compound. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO200211922261204 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | lt,TEX gt,$ alpha$ lt,/TEX gt,-phenyl-n-tert-butyl nitrone (PBN),blood-brain barrier (BBB) permeability |