| 초록 |
Applying sol gel based coatings to orthopedic metallic implant materials can significantly improve their properties and lifespan in vivo. For this work, niobium (Nb 2 O 5 ) and titanium (TiO 2 ) oxides were prepared via solution processing in order to determine the effect of atomic arrangement (amorphous/crystalline) on bioactivity. Thermal evaluation on the synthesized materials identified an endotherm for Nb 2 O 5 at 75 o C with 40% weight loss below 400 o C, and minimal weight loss between 400 and 850 o C. Regarding TiO 2 an endotherm was present at 92 o C with 25% weight loss below 400 o C, and 4% between 400 and 850 o C. Phase evolution was determined using High Temperature X-ray Diffraction (HT-XRD) where amorphous-Nb 2 O 5 (450 o C), hexagonal-Nb 2 O 5 (525 o C), orthorhombic-Nb 2 O 5 (650 o C), amorphous-TiO 2 (275 o C) and tetragonal TiO 2 (500 o C) structures were produced. Simulated body fluid (SBF) testing was conducted over 1, 7 and 30days and resulted in positive chemical and morphological changes for crystalline Nb 2 O 5 (525 o C) and TiO 2 (500 o C) after 30days of incubation. Rod-like CaP deposits were observed on the surfaces using Scanning Electron Microscopy (FE-SEM) and Grazing Incidence-X-ray Diffraction (GI-XRD) shows that the deposits were X-ray amorphous. Cell viability was higher with the TiO 2 (122%) samples when compared to the growing cell population while Nb 2 O 5 samples exhibited a range of viability (64-105%), partially dependent on materials atomic structure. |
