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논문 기본정보
Mammalian Target of Rapamycin 신호전달체계와 우울증
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 생물정신의학 = Korean journal of biological psychiatry |
| ISSN | 1225-8709,2005-7571 |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 이정구,서미경,박성우,김영훈 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2016-01-01 |
| 초록 | Depression is a complicated psychiatric illness with severe consequences. Despite recent advanced achievements of molecular neurobiology, pathophysiology of depression has not been well elucidated. Among new findings of pathophysiology of depression, the possible fast antidepressant effect by N-methyl-D-asparate receptor antagonist, such as ketamine, is regarded as a promising treatment target of depression. Ketamine stimulates the mammalian target of rapamycin (mTOR) signaling pathway and activation of mTOR signaling pathway may be a key mechanism of the antidepressant effect of ketamine. Thus, this review describes the role of mTOR signaling in the pathophysiology of depression and developing a new treatment target of depression. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201612460482973 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | 우울증,NMDA 수용체,케타민,병리생리학,Depression,Mammalian target of rapamycin,N-methyl-D-asparate receptor,Ketamine,Pathophysiology |