| 저자(한글) |
서민수,조성대,안남식,정지원,양세란,박준석,박기수,홍인선,조은혜 |
| 초록 |
A nonspecific immunostimulator $BARODON^{ circledR}$ was tested for mutagenicity using Ames Salmonella tester strains TA98, TA1 00, TA 102, TA 1535 and TA 1537 with or without metabolic activation (59 mix). None of the fresh species showed mutagenicity. In the reverse mutation test using Salmonella phimurium TA98, TA100, TA102, TA1535 and TA1537 did not increase the number of revertants at all doses tested (5, 2.5 or 1.25 mg/ml). Chromosome aberration test was carried out in Chinese hamster lung (CHL) cell line. The cells were treated with $BARODON^{ circledR}$ (1, 0.5 or 0.25 mg/ml), while positive control group was treated with Mitomycin C (0.1 mg/ml). The results show that there is no statistically significant difference between positive control and treatment groups. In mouse micronucleus test, there was significant increase in the ratio of micronucleated polychromatic erythrocyte (MNPCE) in the high dose group (10% $BARODON^{ circledR}$ ), while there is no significance between control and low (2.5% $BARODON^{ circledR}$ ) or middle (5% $BARODON^{ circledR}$ dose groups. Taken together, this results suggest that below 5% $BARODON^{ circledR}$ might not have mutagenic potential in vitro and vivo systems. |
