| 초록 |
The pharmacokinetics of erythromycin (EM) after oral administration was studied in the cultured olive flounder, Paralichthys olivaceus, using LC/MS/MS. After single- or multiple-dose administration of EM (50, 100, 200 mg/kg body weight and 50 mg/kg for 5 days) by oral route in olive flounder ( $350{ pm}40g$ , $22{ pm}0.5^{ circ}C$ ), the concentration in the serum was determined at 1, 3, 6, 9, 24, 72, 120, 168, 264, 360, 504 and 720 h post-dose. The kinetic profile of absorption, distribution and elimination of EM in serum were analyzed fitting to a two-compartment model by WinNonlin program. The area under the concentration-time curve (AUC), maximum concentration ( $C_{max}$ ), time for maximum concentration ( $T_{max}$ ) following oral administration of 50, 100 and 200 mg/kg b.w. and 50 mg for 5 days. EM was $165.3hr^*{ mu}g/m{ ell}$ ( $C_{max}$ , $34.63{ mu}g/m{ ell}$ ; $T_{max}$ , 1.56 hr), $212.8hr^*{ mu}g/m{ ell}$ ( $C_{max}$ , $60.38{ mu}g/m{ ell}$ ; $T_{max}$ , 3.99 hr), and $592.37hr^*{ mu}g/m{ ell}$ ( $C_{max}$ , $63.01{ mu}g/m{ ell}$ ; $T_{max}$ , 4 hr), respectively. The results of this study related to dosage and ${ mu}{ cdot}$ withdrawal times could be used for prescription of EM in field for the treatment of bacterial diseases in olive flounder. |
