| 초록 |
OBJECTIVE To approach the effect of empirically applying β-lactam antibiotics for treatment of hospital- acquired pneumonia on distribution and antibiotic-resistance of pathogenic bacteria. METHODS To investigate 141 patients with hospital-acqired pneumonia in intensive care unit during Jan 2001-Oct 2005, and divide into 3 groups; third generation cephalosporin group; lactamase inhibitor group; and other lactam antibiotics group according to different initial antibacterial strategy, then analyze difference in distribution and antibiotic-resistance of pathogens among each group. RESULTS We acquired 164 strains of pathogens. Comparing with other two groups, the proportion of Gram-positive cocci in lactamase inhibitor group was higher significantly(P〈0.05). Drug-sensibility to β-lactam antibiotics in third generation cephalosporin group was lower than in other lactam antibiotics group, but this difference was not significant. Comparing with third generation cephalosporin group, in lactamase inhibitor group drug-sensibility of Gram-negative bacilli to β-lactam antibiotics increased significantly. CONCLUSIONS Either the efficacy or the effects on distribution and antibiotic-resistance of pathogens must be considered during selecting empiric antibacterial therapy. Meanwhile bacterial culture and susceptibility test must be rechecked in time. |
