| 초록 |
OBJECTIVE To determine the bacterial distribution and resistance of biliary tract infections in China. METHODS Disc diffusion test, MIC test or E-test were used to detect the antimicrobial sensitivity of bacterial isolates from bile specimens. WHONET software was applied for analysis of the bacterial sensitive data from 84 tertiary Mohnarin member hospitals at different area in China from June 1, 2006 to May 31, 2007. RESULTS A total of 1441 bacterial strains were collected in the survey period, which included 952 Gram-negative strains (66.1%) , of which the top three were Escherichia coli (31.0%) ,Klebsiella pneumoniae (8.4%) and Pseudo- monasaeruginosa (7.8%) and 489 Gram-positive strains (33. 9%), the top three were Enterococcus faecalis (11.6M), E. faecium (9.5%) and Staphylococcus ( 7.4 %). Susceptibility results showed that the resistant rates of E. coli and K. pneumoniae to three generation cephalosporins and quinolones were 25. 9-70.0%, 17.9- 44.8% and 66.9-70.9%, 34.6-40.0%, respectively, which were comparable with the results of overall bacteria collection. The resistant rates of P. aeruginosa to imipenem and cefoperazone/sulbactam were 37.5 %, 13.8%, and the detection rate of meticillin-resistant Staphylococcus aureus (MRSA) from bile samples was higher than the results of overall bacteria collection. Vancomycin-resistant Enterococcus (VRE) were rare. CONCLUSIONS Gram- negative bacilli are still the predominant pathogens in biliary tract infections l the overall bacterial resistance is severe. MRSA is increasing. Prudent application of antibiotics in biliary tract infections needs to be emphasized. |
